Agree with John & Ken's comments.
These issues have plagued 5D users already
One design (think it was Leica) correct it by adjusting the microlens array that sits on top of the CCD. The microlenses on the edges are slightly offset to compensate for the angle of incidence.

Even the K20D reportedly improved things by semiconductor changes to the CMOS sensor. The photosites were positioned closer to the surface so the "pits" were not as deep as other sensors.

So, yes, it's a problem. And yes, it can be worked around.
And yes, it costs money

Matt

Took the 50-135 in the pouring rain
Not a problem. Just dried it with a towel, then left it out to dry out naturally.

Matt

Definitely, definitely get Vuescan

You can set it up to do batches of slides and negs. I did thousands that way while working on other things (just feeding the scanner).

Matt

If it's any help, I find that when developing RAW files with Silkypix that the hot pixels are automatically mapped out

Matt

Whoops! My mistake. I was referring to the Pentax 17-70 That's SDM only.
I don't have any experience with the Sigma.

(If you're working in that range, then the old Pentax FA 24-90 is rather a lovely lens. Very light and compact with beautiful rendering.)

Matt

As you've already ordered it - let's see what you think when you get it.

My view - it's a gem
(Only tiny little snag is that it's SDM only and won't work on the screw-drive-only cameras like the *ist-D).
Matt

Dust bunnies almost certainly
(Watch out they don't start breeding :lol
Use the dust mapping feature to show where they are, and how big.

Try the sensor clean function.
If that fails, a Rocket Blower normally does the trick.

Realistically dust is always going to be a problem. However, I've found the K20D much, much better at handling dust than the *ist-D (which needed wet cleaning all the time).

Matt

It does also depend what firmware in the K10D
The early versions didn't support SDM focussing.
(Hold down the MENU button while turning on the power to check)
Matt

Alas, I have an Optech strap - once you've used one of these you won't move to anything else

Enamel or embroidered badge for me... or perhaps "wearables" (T-shirt, hat, etc)

Matt

Just found this today on the BBC news website and thought this may be interesting

http://news.bbc.co.uk/1/low/magazine/8253915.stm

Matt